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Recombinant Human IL1RAPL1 protein(Met1-Leu354), His-tagged

Cat.No. : IL1RAPL1-777H
Product Overview : Recombinant Human IL1R8 (NP_055086.1) extracellular domain (Met 1-Leu 354) was expressed in HEK293 with a C-terminal polyhistidine tag.
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Source : HEK293
Species : Human
Tag : C-His
Protein length : Met1-Leu354
Form : Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human IL1R8 consists of 347 amino acids and has a predicted molecular mass of 40 kDa. As a result of glycosylation, the apparent molecular mass of rh IL1R8 is approximately 50-55 kDa in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg of the protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : IL1RAPL1 interleukin 1 receptor accessory protein-like 1 [ Homo sapiens ]
Official Symbol : IL1RAPL1
Synonyms : IL1RAPL1; interleukin 1 receptor accessory protein-like 1; IL1RAPL, mental retardation, X linked 10 , mental retardation, X linked 21 , mental retardation, X linked 34 , MRX10, MRX21, MRX34; interleukin-1 receptor accessory protein-like 1; IL1R8; OPHN4; TIGIRR 2; IL1RAPL-1; IL-1RAPL-1; IL-1-RAPL-1; oligophrenin-4; interleukin 1 receptor-8; mental retardation, X-linked 10; X-linked interleukin-1 receptor accessory protein-like 1; three immunoglobulin domain-containing IL-1 receptor-related 2; MRX10; MRX21; MRX34; IL1RAPL; TIGIRR-2;
Gene ID : 11141
mRNA Refseq : NM_014271
Protein Refseq : NP_055086
MIM : 300206
UniProt ID : Q9NZN1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can IL1RAPL1 mutations be linked to specific neurological disorders? 06/27/2022

Linked to intellectual disabilities.

How does IL1RAPL1 expression vary in different brain regions? 01/27/2022

Higher in the hippocampus and cortex.

How does IL1RAPL1 expression change during neural development? 10/01/2021

Increases during early development, decreases in adulthood.

How does IL1RAPL1 interact with other members of the IL-1 receptor family? 07/27/2021

Forms heterodimers with IL-1RI.

How does IL1RAPL1 interact with PSD-95 in neurons? 12/22/2020

Binds directly to the PDZ domains of PSD-95.

What is the role of IL1RAPL1 in synaptic plasticity? 09/28/2020

Involved in excitatory synapse formation.

Is IL1RAPL1 expression affected by neuroinflammatory conditions? 02/26/2020

Upregulated in neuroinflammatory conditions.

Does IL1RAPL1 have any alternative splicing variants? 04/09/2019

Yes, multiple isoforms exist.

What post-translational modifications occur on IL1RAPL1? 08/01/2018

Subject to ubiquitination.

Does IL1RAPL1 have a role in dendritic spine morphology? 06/12/2018

Affects spine density and shape.

Customer Reviews (3)

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Reviews
07/08/2022

    Effective in inflammation studies.

    03/20/2020

      High specificity.

      07/30/2017

        Suitable for cytokine assays.

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