"IL6R" Related Products

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Recombinant Human Interleukin 6 Receptor

Cat. No.: IL6R-584H
Product Overview: Recombinant human sIL-6R is a 37.6 kDa protein consisting of the extracellular domain of the IL-6R alpha chain (338 amino acid residues). It is produced inHEK 293 cells.
Description: IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. The IL-6R alpha chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R alpha. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits.
Source: HEK 293 cells.
Amino Acid Sequence: LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH ASGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPAPPA NITVTAVARN PRWLSVTWQD PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQD.
Note: If this material is not to be used for coating or labeling or other applications requiring carrier free material), the addition of 0.1% BSA to dilution buffers or dilution in sterile culture media is recommended to enhance stability and minimize absorption to vial.
Supplied: The sterile filtered solution was lyophilized from 1 x PBS, pH 7.2.
Purity: >98% by SDS-Page analysis and HPLC analyses. Endotoxin level is less than 0.1ng per ug (1EU/UG) of IL-6R.
Reconstitution: We recommend a quick spin followed by reconstitution in 1 x PBS, pH 7.2 to a concentration of 0.1-1.0 mg/ml. Allow to set at least 10 minutes.
Reactivity: The ED50 as determined by it"s ability to intensify the IL-6 induced growth inhibition of murine M1 cells is < 10.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Storage: The lyophilized powder is stable at room temperature for a few weeks but it is best stored desiccated at -20℃. Reconstituted IL-6R should be stored in working aliquots at -20℃. Avoid frequent freeze thaw cycles.
Gene Name: IL6R interleukin 6 receptor [ Homo sapiens ]
Synonyms: IL6R; interleukin 6 receptor; CD126; IL6RA; IL-6R-1; MGC104991; IL-6R-alpha; CD126 antigen; interleukin 6 receptor alpha subunit; IL-6R 1; gp80; Membrane glycoprotein 80
Gene ID: 3570
mRNA Refseq: NM_000565
Protein Refseq: NP_000556
MIM: 147880
UniProt ID: P08887
Chromosome Location: 1q21
Pathway: Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Jak-STAT signaling pathway
Function: ciliary neurotrophic factor binding; ciliary neurotrophic factor receptor activity; enzyme binding; interleukin-6 receptor activity; protein homodimerization activity; receptor activity

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