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| Cat. No.: | Cxcl1-94R |
| Product Overview: | Recombinant Rat GRO produced inE.coliis an 8.0 kDa protein containing 72 amino acid residues. |
| Description: | CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis.CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. An initial study in mice showed evidence that CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. |
| Source: | E.coli. |
| Purity: | > 98% (SDS-PAGE; HPLC). |
| Endotoxin level: | < 0.1 ng/μg of GRO. |
| Stabilizer: | None. |
| Formulation: | Lyophilized. |
| Biologically Activity: | The maximal chemotactic activity of rat GRO on rat neutrophils as assayed in a modified Boyden chamber was achieved at 10-100 ng/ml. |
| Reconstitution: | The lyophilized rat GRO is soluble in water and most aqueous buffers. The lyophilized powder should be reconstituted in water to a concentration of 100 μg/ml. This solution can be diluted into water or other buffered solutions or stored at -20°C for future use. |
| Stability: | The lyophilized powder, though stable at room temperature, is best stored desiccated below 0°C. Reconstituted rat GRO should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles. |
| Gene Name: | Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [ Rattus norvegicus ] |
| Synonyms: | Cxcl1; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha); Gro1; CINC-1; cytokine-induced neutrophil chemoattractant 1; Gro; chemokine (C-X-C motif) ligand 1 |
| Gene ID: | 81503 |
| mRNA Refseq: | NM_030845 |
| Protein Refseq: | NP_110472 |
| UniProt ID: | P14095 |
| Chromosome Location: | p22 |
| Pathway: | Chemokine signaling pathway; Cytokine-cytokine receptor interaction |
| Function: | chemokine activity; growth factor activity |
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