"Il21" Related Products

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Recombinant Mouse Interleukin 21

Cat. No.: Il21 -169M
Product Overview: Recombinant murine IL-21 is a 15.0 kDa protein consisting of 130 amino acid residues. It was expressed inE.Coli.
Description: IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated-B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3.
Source: E.Coli.
Purity: > 98% by SDS-PAGE.
Endotoxin Level: < 0.1 ng per μg of IL-21.
Stabilizer: None.
Formulation: Lyophilized.
Biological Activity: Testing in progress!
Stability: The lyophilized protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted IL-21 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze-thaw cycles.
Gene Name: Il21 interleukin 21 [ Mus musculus ]
Synonyms: interleukin 21; Il21; OTTMUSP00000007838
Gene ID: 60505
mRNA Refseq: NM_021782
Protein Refseq: NP_068554
UniProt ID: Q9ES17
Chromosome Location: 3 B
Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function: cytokine activity; cytokine receptor binding

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