Recombinant Rat GNAS Complex Locus

• Cat.No.: Gnas-1045R

Specification

• Cat. No.: Gnas-1045R
• Description: GsαS is the short splice variant of theα-subunit of stimulatory heterotrimeric Gs-proteins. In contrast to the long splice variant (GsαL) GsαS lacks the 15-amino acid insert between the Ras like and the α-helical domain. GsαS activates adenylate cyclase (AC) and possesses a higher GDP-affinity than GsαL. The differences in GDP-binding between GsαS and GsαL have important consequences for receptor/G-protein coupling and activation.
• Source: Sf9 insect cells.
• Form: Membrane suspension. Supplied in 75 mM, Tris-HCl, pH 7.4, 12.5 mM MgCl2 and 1 mM EDTA.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months. Store at -80°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: Gnas GNAS complex locus [ Rattus norvegicus ]
• Synonyms: Gnas; GNAS complex locus; Gnas; Gnas1
• Gene ID: 24896
• mRNA Refseq: NM_001024823
• Protein Refseq: NP_001019994
• UniProt ID: P63095
• Chromosome Location: 3q42
• Pathway: Calcium signaling pathway; Dilated cardiomyopathy; Gap junction; GnRH signaling pathway; Long-term depression; Melanogenesis; Taste transduction; Vascular smooth muscle contraction
• Function: GTP binding; guanyl nucleotide binding; identical protein binding; mu-type opioid receptor binding; nucleotide binding; protein binding; signal transducer activity