"Pggt1b" Related Products

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Recombinant Rat Pggt1b, GST-tagged

Cat. No. : Pggt1b-325R
Description : GGTase-I (Geranylgeranyltransferase-I) catalyzes the transfer of the farnesyl and geranylgeranyl groups from farnesyl and geranylgeranyl-diphosphate to proteins ontaining a C-terminal CaaX motif, where 'C' is a conserved cysteine that is the site of farnesyl modification, 'a' is usually an aliphatic amino acid, and 'X' is leucine or phenylalanine. Farnesyltransferase (FT) and GGTase-I are closely related, sharing a common subunit and 30% identity in their β subunits. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
Source : E. coli.
Form : Liquid. Supplied in 25 mM HEPES, pH 7.2, 25 mM NaCl and 5 mM DTT.
Purity : > 90% by SDS-PAGE.
Activity : 1 pmol of GGTase-I will transfer 5 pmol of Farnesyl to RhoA in 15 min at 37°C.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles.
Gene Name : Pggt1b protein geranylgeranyltransferase type I, beta subunit [ Rattus norvegicus ]
Synonyms : Pggt1b; protein geranylgeranyltransferase type I, beta subunit; geranylgeranyltransferase type 1 beta; geranylgeranyltransferase type I (GGTase-I)
Gene ID : 81746
mRNA Refseq : NM_031082
Protein Refseq : NP_112344
UniProt ID : P53610
Chromosome Location : q11
Function : CAAX-protein geranylgeranyltransferase activity; drug binding; isoprenoid binding; metal ion binding; peptide binding; prenyltransferase activity; protein binding; transferase activity; zinc ion binding

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