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||GGTase-I (Geranylgeranyltransferase-I) catalyzes the transfer of the farnesyl and geranylgeranyl groups from farnesyl and geranylgeranyl-diphosphate to proteins ontaining a C-terminal CaaX motif, where 'C' is a conserved cysteine that is the site of farnesyl modification, 'a' is usually an aliphatic amino acid, and 'X' is leucine or phenylalanine. Farnesyltransferase (FT) and GGTase-I are closely related, sharing a common subunit and 30% identity in their β subunits. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
||Liquid. Supplied in 25 mM HEPES, pH 7.2, 25 mM NaCl and 5 mM DTT.
||> 90% by SDS-PAGE.
||1 pmol of GGTase-I will transfer 5 pmol of Farnesyl to RhoA in 15 min at 37°C.
||For in vitro use only.
||Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles.