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||Retinoic acid receptors are important in the regulation of growth and differentiation of epithelial tissues, embryonic and central nervous system development and hematopoiesis. Retinoids mediate their effect by two classes of nuclear receptor proteins, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), that each consist of three isotypes (α,β, and γ) encoded in separate genes. Upon dimerization with RXR, RARs can bind to specific enhancer sequences in the DNA, socalled retinoic acid response elements (RAREs), resulting in transcriptional activation of target genes in the presence of ligand. Retinoids, the natural and synthetic vitamin A derivatives, are known to inhibit the proliferation of lung cancer and breast cancer cells and the growth of carcinogen-induced bronchogenic squamous cell carcinoma and mammary tumors, and have been used as chemoprevention agents against both types of cancer. A growing body of evidence supports the hypotheses that the RAR beta gene is a tumor suppressor gene and the chemopreventive effects of retinoids are due to induction of RAR beta. RAR beta expression is reduced in many malignant tumors including breast carcinoma.MW = 55 kDa.
||Sf9 insect cells.
||> 90% by SDS-PAGE.
||Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
||20-100 ng are sufficient for an in vitro transcription assay and 100 ng are sufficient for a protein-protein interaction assay.
||RAR beta has been applied in in vitro transcription assays, DNA and protein-protein interaction assays.
||Quality guaranteed for 12 months. Store at -80°C.Avoid freeze / thaw cycles.
||For in vitro use only.
||Non-small cell lung cancer; Pathways in cancer; Small cell lung cancer