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Recombinant Human Growth Differentiation Factor 5, His-tagged

Cat.No. : GDF-5300H
Product Overview : Recombinant Human GDF5 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 141 amino acids (382-501 aa) and having a total molecular mass of 15.8 kDa. GDF5 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
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  • Gene Information
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Cat. No. : GDF5-300H
Description : GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
Source : Escherichia Coli.
Amino Acid Sequence : MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R
Purity : Greater than 95.0% as determined by SDS-PAGE.
Physical Appearance : Sterile Filtered colorless solution.
Formulation : The GDF5 solution contains 10mM sodium citrate pH3.5 and 10% glycerol.
Stability : GDF5 although stable 4℃ for 4 weeks, should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name : GDF5 growth differentiation factor 5 [ Homo sapiens ]
Synonyms : GDF5; Growth Differentiation Factor 5; OS5; LAP4; BMP14; CDMP1; SYNS2; cartilage-derived morphogenetic protein-1; OTTHUMP00000030755; CDMP-1; GDF-5; Radotermin; BMP-14; OTTHUMP00000061644
Gene ID : 8200
mRNA Refseq : NM_000557
Protein Refseq : NP_000548
MIM : 601146
UniProt ID : P43026
Chromosome Location : 20q11
Pathway : Cytokine-cytokine receptor interaction; TGF-beta signaling pathway
Function : cytokine activity; growth factor activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does GDF5 contribute to cartilage repair? 10/10/2022

GDF5 has been found to stimulate the proliferation and differentiation of chondrocytes, the cells responsible for cartilage formation and maintenance.

What preclinical evidence supports the use of GDF5 in orthopedics? 01/16/2021

Preclinical studies have demonstrated GDF5's ability to promote bone and cartilage regeneration in animal models, providing a foundation for further clinical exploration.

How does GDF5 differ from other growth factors in terms of clinical applications? 10/01/2017

GDF5's specificity for bone and cartilage development distinguishes it from other growth factors, making it a targeted option for orthopedic interventions.

Can GDF5 be used in combination with other therapies for enhanced effects? 09/06/2017

Some studies suggest that combining GDF5 with other growth factors or therapeutic approaches may result in synergistic effects, improving overall outcomes.

Is GDF5 only relevant for bone and cartilage conditions, or are there other potential applications? 08/18/2017

While its primary focus is on musculoskeletal conditions, GDF5's role in cellular differentiation opens avenues for exploring its applications in broader regenerative medicine contexts.

Customer Reviews (3)

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Reviews
06/26/2022

    Their dedicated team of experts is prompt, knowledgeable, and readily available to tackle any hurdles or concerns I may encounter.

    03/20/2020

      Used in protein electron microscopy structure analysis.Great.

      08/31/2019

        By harnessing the power of the GDF5 protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.

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