Recombinant Human Growth Differentiation Factor 5, His-tagged
Cat.No. : | GDF-5300H |
Product Overview : | Recombinant Human GDF5 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 141 amino acids (382-501 aa) and having a total molecular mass of 15.8 kDa. GDF5 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | GDF5-300H |
Description : | GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. |
Source : | Escherichia Coli. |
Amino Acid Sequence : | MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R |
Purity : | Greater than 95.0% as determined by SDS-PAGE. |
Physical Appearance : | Sterile Filtered colorless solution. |
Formulation : | The GDF5 solution contains 10mM sodium citrate pH3.5 and 10% glycerol. |
Stability : | GDF5 although stable 4℃ for 4 weeks, should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Gene Name : | GDF5 growth differentiation factor 5 [ Homo sapiens ] |
Synonyms : | GDF5; Growth Differentiation Factor 5; OS5; LAP4; BMP14; CDMP1; SYNS2; cartilage-derived morphogenetic protein-1; OTTHUMP00000030755; CDMP-1; GDF-5; Radotermin; BMP-14; OTTHUMP00000061644 |
Gene ID : | 8200 |
mRNA Refseq : | NM_000557 |
Protein Refseq : | NP_000548 |
MIM : | 601146 |
UniProt ID : | P43026 |
Chromosome Location : | 20q11 |
Pathway : | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
Function : | cytokine activity; growth factor activity; protein binding |
Products Types
◆ Recombinant Protein | ||
GDF5-299H | Active Recombinant Human GDF5 Protein (Ala382-Arg501), C-His tagged, Animal-free, Carrier-free | +Inquiry |
GDF5-275H | Recombinant Human GDF5 Protein, His-tagged | +Inquiry |
GDF5-107H | Active Recombinant Human GDF5 Protein | +Inquiry |
GDF5-4827H | Recombinant Human GDF5 Protein, GST-tagged | +Inquiry |
GDF5-049H | Active Recombinant Human GDF5 Protein | +Inquiry |
◆ Lysates | ||
GDF5-5968HCL | Recombinant Human GDF5 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionGDF5 has been found to stimulate the proliferation and differentiation of chondrocytes, the cells responsible for cartilage formation and maintenance.
Preclinical studies have demonstrated GDF5's ability to promote bone and cartilage regeneration in animal models, providing a foundation for further clinical exploration.
GDF5's specificity for bone and cartilage development distinguishes it from other growth factors, making it a targeted option for orthopedic interventions.
Some studies suggest that combining GDF5 with other growth factors or therapeutic approaches may result in synergistic effects, improving overall outcomes.
While its primary focus is on musculoskeletal conditions, GDF5's role in cellular differentiation opens avenues for exploring its applications in broader regenerative medicine contexts.
Customer Reviews (3)
Write a reviewTheir dedicated team of experts is prompt, knowledgeable, and readily available to tackle any hurdles or concerns I may encounter.
Used in protein electron microscopy structure analysis.Great.
By harnessing the power of the GDF5 protein, I can harness its outstanding quality and tap into its potential to obtain dependable and meaningful findings.
Ask a Question for All GDF5 Products
Required fields are marked with *
My Review for All GDF5 Products
Required fields are marked with *
Inquiry Basket