Cat. No. : |
IRAK4-333H |
Product Overview : |
Recombinant full-length human IRAK4 was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 81 kDa. |
Description : |
Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members. IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is the Ser/Thr kinase activity which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol. |
Source : |
Sf9 insect cells using baculovirus. |
Sequence : |
Full-length. |
Applications : |
Kinase Assay, Western Blot. |
Storage And Stability : |
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |