"IRAK4" Related Products

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Recombinant Human IRAK4, GST-tagged, Active

Cat. No. : IRAK4-333H
Product Overview : Recombinant full-length human IRAK4 was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 81 kDa.
Description : Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members. IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is the Ser/Thr kinase activity which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ]
Synonyms : IRAK4; interleukin-1 receptor-associated kinase 4; IPD1; REN64; NY-REN-64; EC 2.7.11.1; IRAK-4; NY-REN-64 antigen
Gene ID : 51135
mRNA Refseq : NM_001114182
Protein Refseq : NP_001107654
MIM : 606883
UniProt ID : Q9NWZ3
Chromosome Location : 12q12
Pathway : Apoptosis; Neurotrophin signaling pathway; Toll-like receptor signaling pathway
Function : ATP binding; interleukin-1 receptor binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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