Cat. No. :	IRAK4-333H
Product Overview :	Recombinant full-length human IRAK4 was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 81 kDa.
Description :	Interleukin-1 receptor-associated kinase 4 (IRAK4) is an important mediator in the signal transduction of Toll-like receptor (TLR) and IL1R family members. IRAK4 is involved in the Toll-like receptor signaling pathway leading to Apoptosis. IRAK4 has molecular functions like protein binding, ATP binding, kinase activity and magnesium ion binding. Toll/IL-1 receptor family members like IRAK4 are central components of host defense mechanisms in a variety of species. One well conserved element in their signal transduction is the Ser/Thr kinase activity which couple early signaling events in a receptor complex at the plasma membrane to larger signalosomes in the cytosol.
Source :	Sf9 insect cells using baculovirus.
Sequence :	Full-length.
Applications :	Kinase Assay, Western Blot.
Storage And Stability :	Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Name :	IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ]
Synonyms :	IRAK4; interleukin-1 receptor-associated kinase 4; IPD1; REN64; NY-REN-64; EC 2.7.11.1; IRAK-4; NY-REN-64 antigen
Gene ID :	51135
mRNA Refseq :	NM_001114182
Protein Refseq :	NP_001107654
MIM :	606883
UniProt ID :	Q9NWZ3
Chromosome Location :	12q12
Pathway :	Apoptosis; Neurotrophin signaling pathway; Toll-like receptor signaling pathway
Function :	ATP binding; interleukin-1 receptor binding; magnesium ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; transferase activity

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