"INSRR" Related Products

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Recombinant Human Insulin Receptor-related Receptor, GST-tagged, Active

Cat. No. : INSRR-334H
Product Overview : Recombinant human IRR (945-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 65 kDa.
Description : IRR or insulin receptor-related receptor is a tyrosine protein kinase that is required for the appearance of male gonads and thus for male sexual differentiation. The expression of IRR mRNA is restricted to a few tissue types and has been detected in neuronal tissues as well as in neuroblastomas. As a result of its occurrence in neuroblastomas, it has speculated that IRR may be involved in tumor genesis. RT-PCR and solution hybridization/RNAse protection assay have shown strong coupling of IRR mRNA in 18 tumor cell lines.
Source : Sf9 insect cells using baculovirus.
Sequence : 945-end.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : INSRR insulin receptor-related receptor [ Homo sapiens ]
Synonyms : INSRR; insulin receptor-related receptor; IRR; IR-related receptor; EC 2.7.10.1; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; OTTHUMP00000038715
Gene ID : 3645
mRNA Refseq : NM_014215
Protein Refseq : NP_055030
MIM : 147671
UniProt ID : P14616
Chromosome Location : 1q21-q23
Pathway : Prostate cancer; Regulation of actin cytoskeleton
Function : ATP binding; manganese ion binding; metal ion binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

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