"STK4" Related Products

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Recombinant Human Serine/Threonine Kinase 4, GST-tagged, Active

Cat. No. : STK4-361H
Product Overview : Recombinant full-length human MST1 was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 83 kDa.
Description : MST1 belongs to a family of proteins that share similarity with a budding yeast serine/threonine kinase, sterile-20 (Ste20). Endogenous full-length MST1 is activated by a variety of stressful stimuli, accompanied by the secondary appearance of a 36 kDa Thr183-phosphorylated, caspase-cleaved catalytic fragment. Recombinant MST1 undergo a robust autoactivation in vitro, mediated by an intramolecular autophosphorylation on the activation loop of an MST dimmer. MST1 can initiate apoptosis when transiently overexpressed in mammalian cells. Interference with the ability of endogenous MST1 to associate with the putative tumor suppressor proteins Nore1/RASSF can inhibit Ras-induced apoptosis.
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : STK4 serine/threonine kinase 4 [ Homo sapiens ]
Synonyms : STK4; serine/threonine kinase 4; KRS2; MST1; YSK3; DKFZp686A2068; yeast Ste20-like; mammalian sterile 20-like 1; kinase responsive to stress 2; dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); EC 2.7.11.1; MST-1; OTTHUMP00000043418; Mammalian STE20-like protein kinase 1; STE20-like kinase MST1; Serine/threonine-protein kinase Krs-2; Serine/threonine-protein kinase 4
Gene ID : 6789
mRNA Refseq : NM_006282
Protein Refseq : NP_006273
MIM : 604965
UniProt ID : Q13043
Chromosome Location : 20q11.2-q13.2
Pathway : MAPK signaling pathway; Non-small cell lung cancer; Pathways in cancer
Function : ATP binding; magnesium ion binding; nucleotide binding; protein homodimerization activity; protein serine/threonine kinase activity; transcription factor binding; transferase activity

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