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Recombinant Human RPS6KB1, His-tagged, Active

Cat.No. : RPS6KB1-376H
Product Overview : Recombinant full-length human RPS6KB1 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal His tag. MW=76 kDa.
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Cat. No. : RPS6KB1-376H
Description : P70S6K is responsible for the phosphorylation of 40S ribosomal protein S6 and is ubiquitously expressed in human adult tissues. p70S6K is activated by serum stimulation and this activation is inhibited by wortmannin and rapamycin. p70S6k activity undergoes changes in the cell cycle and increases 20-fold in G1 cells released from G0. p70S6K activation requires sequential phosphorylations at proline-directed residues in the putative autoinhibitory pseudosubstrate domain, as well as threonine 389 a site phosphorylated by phosphoinositide-dependent kinase 1 (PDK-1).
Source : Sf9 insect cells using baculovirus.
Sequence : Full-length.
Applications : Kinase Assay, Western Blot.
Storage And Stability : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name : RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 [ Homo sapiens ]
Synonyms : RPS6KB1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6K; PS6K; S6K1; STK14A; p70-S6K; p70-alpha; p70(S6K)-alpha; p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; serine/threonine kinase 14 alpha; EC 2.7.11.1
Gene ID : 6198
mRNA Refseq : NM_003161
Protein Refseq : NP_003152
MIM : 608938
UniProt ID : P23443
Chromosome Location : 17q23.1
Pathway : Acute myeloid leukemia; ErbB signaling pathway; Fc gamma R-mediated phagocytosis; Insulin signaling pathway; TGF-beta signaling pathway; mTOR signaling pathway; Signaling by Insulin receptor
Function : ATP binding; nucleotide binding; peptide binding; protein binding; ribosomal protein S6 kinase activity; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which RPS6KB1 modulates autophagy and cell survival? 04/14/2022

RPS6KB1 regulates autophagy and cell survival, crucial for cellular health and response to stress.

How does RPS6KB1 (Ribosomal Protein S6 Kinase B1) regulate protein synthesis and cell growth? 02/22/2021

RPS6KB1 controls protein synthesis and cell growth, playing a key role in cellular proliferation.

What is the impact of RPS6KB1 on cellular responses to stress and DNA damage? 05/22/2020

RPS6KB1 impacts cellular stress responses, including the repair of DNA damage and maintenance of genomic stability.

How does RPS6KB1 contribute to the development and progression of cancer? 01/07/2020

RPS6KB1 can contribute to cancer by promoting tumor cell growth and proliferation.

What role does RPS6KB1 play in the mTOR signaling pathway, particularly in response to nutrient availability? 08/26/2019

RPS6KB1 is a critical component of the mTOR pathway, responding to nutrient signals to regulate cell metabolism and growth.

How do alterations in RPS6KB1 expression or activity affect aging and age-related diseases? 03/05/2019

Changes in RPS6KB1 function can affect aging processes and the development of age-related diseases.

How does RPS6KB1 influence metabolic processes, especially in conditions like obesity and diabetes? 02/13/2018

RPS6KB1 influences metabolic processes, affecting how cells respond to conditions like obesity and diabetes.

Customer Reviews (3)

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Reviews
09/16/2021

    Dependable protein purification, consistently high-quality results.

    06/11/2021

      Precise mass spectrometry analysis, essential for our proteomics work.

      06/30/2019

        Efficient peptide synthesis, crucial for our peptide research projects.

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