"PLK1" Related Products


Recombinant Human Polo-like Kinase 1 (Drosophila), His-tagged, Active

Cat. No.: PLK1-412H
Product Overview: Recombinant full-length human PLK1 was expressed bybaculovirusinSf9 insect cellsusing an N-terminal His tag. MW=70kDa.
Description: PLK1 is a member of the Polo-Like Kinase family that localize to centrosomes or spindle pole bodies and undergo dramatic subcellular relocation during the cell cycle. Deregulated activities of PLKs often result in abnormalities in centrosome duplication, maturation, and/or microtubule dynamics. PLKs also regulate the function of the Golgi complex. Deregulated expression of human PLK1 is strongly correlated with the development of many types of malignancies, and ectopic expression of PLK1 dominant negative protein leads to rapid cell death.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PLK1 polo-like kinase 1 (Drosophila) [ Homo sapiens ]
Synonyms: PLK1; polo-like kinase 1 (Drosophila); PLK; STPK13; polo-like kinase 1; polo like kinase; polo (Drosophia)-like kinase; cell cycle regulated protein kinase; EC; PLK-1; Polo-like kinase 1; Serine/threonine-protein kinase 13; polo like kinase; polo-like kinase 1 (Drosophila); Serine/threonine-protein kinase PLK1
Gene ID: 5347
mRNA Refseq: NM_005030
Protein Refseq: NP_005021
MIM: 602098
UniProt ID: P53350
Chromosome Location: 16p
Pathway: Cell cycle; Progesterone-mediated oocyte maturation
Function: ATP binding; nucleotide binding; polo kinase kinase activity; protein binding; protein serine/threonine kinase activity; transferase activity

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