"TTK" Related Products


Recombinant Human TTK, GST-tagged, Active

Cat. No.: TTK-452H
Product Overview: Recombinant full-length human TTK was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 130kDa.
Description: TTK is a serine/threonine kinase that has been implicated in the regulation of centrosome duplication and mitotic checkpoint response. Overexpressing of dominant-negative TTK in human cell lines prevents centrosome duplication while active TTK accelerates centrosome reduplication in an osteosarcoma cell line. Disruption of TTK function leads to a combination of severe mitotic abnormalities and failure in centrosome duplication. TTK is required for stabilization and activation of p53 during spindle disruption. TTK phoshorylates the N-terminal domain of p53 at Thr18, and this phosphorylation disrupts the interaction with MDM2 and abrogates MDM2-mediated p53 ubiquitination.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: TTK TTK protein kinase [ Homo sapiens ]
Synonyms: TTK; TTK protein kinase; ESK; PYT; CT96; MPS1; MPS1L1; FLJ38280; cancer/testis antigen 96; EC; Phosphotyrosine picked threonine-protein kinase; phosphotyrosine picked threonine kinase (PYT)
Gene ID: 7272
mRNA Refseq: NM_001166691
Protein Refseq: NP_001160163
MIM: 604092
UniProt ID: P33981
Chromosome Location: 6q13-q21
Pathway: Cell cycle
Function: ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity

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