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Recombinant Human PTPN6,GST-tagged,Active

Cat. No.: PTPN6-465H
Product Overview: Recombinant human full length PTPN6 was expressed inE.colicells using a N-terminal GST tag. MW=93kDa.
Description: PTPN6 gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The noncatalytic N-terminus of this PTP can interact with MAP kinases and negatively regulates ERK2 and p38 MAP-kinases activity. The PTPN6 was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway.
Source: E.coli.
Sequence: Full length.
Applications: Phosphatase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PTPN6 protein tyrosine phosphatase, non-receptor type 6 [ Homo sapiens ]
Synonyms: PTPN6; protein tyrosine phosphatase, non-receptor type 6; SHP1; hematopoietic cell phosphatase; protein-tyrosine phosphatase 1C; hematopoietic cell protein-tyrosine phosphatase; EC 3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase SHP-1; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1
Gene ID: 5777
mRNA Refseq: NM_002831
Protein Refseq: NP_002822
UniProt ID: P29350
Chromosome Location: 12p13.31
MIM: 176883
Pathway: Adherens junction; B cell receptor signaling pathway; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; T cell receptor signaling pathway; Hemostasis; Signaling in Immune system
Function: hydrolase activity; protein binding; protein tyrosine phosphatase activity

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