"PDE6B" Related Products

Recombinant Human PDE6B, GST-tagged, Active

Cat. No.: PDE6B-480H
Product Overview: Recombinant Full-length human PDE6B was expressed by baculovirus inSf9insect cells using an N-terminal GST tag. MW = 124 kDa.
Description: PDE6B is a member of the phosphodiesterase family of proteins that play a critical role in regulating intracellular levels of cAMP and cGMP. PDE6B is a high-affinity cGMP-specific PDE that shows high expression in the eye. Four mutations in the PDE6B gene lead to a degenerative disease of photoreceptors called retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Subretinal injection of mice with retinal degeneration with PDE6B gene showed significant decrease in photoreceptor cell death. A nonsense mutation in the PDE6B gene is also the cause of Rod-cone dysplasia-1 (rcd1) in Irish setters.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: PDE Assay.
Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta [ Homo sapiens ]
Synonyms: PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; rd1; PDEB; RP40; CSNB3; phosphodiesterase 6B; rod cGMP-phosphodiesterase beta-subunit; EC 3.1.4.35; congenital stationary night blindness 3, autosomal dominant; GMP-PDE beta; Rod cGMP-specific 3",5"-cyclic phosphodiesterase subunit beta
Gene ID: 5158
mRNA Refseq: NM_000283
Protein Refseq: NP_000274
MIM: 180072
UniProt ID: P35913
Chromosome Location: 4p16.3
Function: 3",5"-cyclic-GMP phosphodiesterase activity; hydrolase activity

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.