Recombinant Human APEX1, T7 -tagged
Cat.No. : | APEX1-27360TH |
Product Overview : | Recombinant full length Human APE1 with an N terminal T7 tag; 332 amino acids with tag, Predicted MWt 36.9 kDa. |
- Specification
- Gene Information
- Related Products
Description : | Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. |
Protein length : | 318 amino acids |
Conjugation : | T7 |
Molecular Weight : | 36.900kDa inclusive of tags |
Source : | E. coli |
Form : | Liquid |
Purity : | >90% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MASMTGGQQMGRGSMPKRGKKGAVA EDGDELRTEPEAKKSKTAAKKNDKE AAGEGPALYEDPPDQKTSPSGKPAT LKICSWNVDGLRAWIKKKGLDWVKE EAPDILCLQETKCSENKLPAELQEL PGLSHQYWSAPSDKEGYSGVGLLSR QCPLKVSYGIGEEEHDQEGRVIVAE FDSFVLVTAYVPNAGRGLVRLEYRQ RWDEAFRKFLKGLASRKPLVLCGDL NVAHEEIDLRNPKGNKKNAGFTPQE RQGFGELLQAVPLADSFRHLYPNTP YAYTFWTYMMNARSKNVGWRLDYFL LSHSLLPALCDSKIRSKALGSDHCP ITLYLAL |
Sequence Similarities : | Belongs to the DNA repair enzymes AP/ExoA family. |
Gene Name : | APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 [ Homo sapiens ] |
Official Symbol : | APEX1 |
Synonyms : | APEX1; APEX nuclease (multifunctional DNA repair enzyme) 1; APEX, APEX nuclease (multifunctional DNA repair enzyme); DNA-(apurinic or apyrimidinic site) lyase; APE; APE 1; APEN; APX; HAP1; REF 1; REF1; |
Gene ID : | 328 |
mRNA Refseq : | NM_001244249 |
Protein Refseq : | NP_001231178 |
MIM : | 107748 |
Uniprot ID : | P27695 |
Chromosome Location : | 14q11.2 |
Pathway : | BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; |
Function : | 3-5 exonuclease activity; 3-5 exonuclease activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-(apurinic or apyrimidinic site) lyase activity; |
Products Types
◆ Recombinant Protein | ||
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APEX1-182R | Recombinant Rhesus Macaque APEX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
APEX1-1330H | Recombinant Human APEX1 Protein (32-318 aa), His-tagged | +Inquiry |
APEX1-617M | Recombinant Mouse APEX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
APEX1-354H | Recombinant Human APEX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
APEX1-8796HCL | Recombinant Human APEX1 293 Cell Lysate | +Inquiry |
APEX1-8797HCL | Recombinant Human APEX1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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