Recombinant Human BRCA2

• Cat.No.: BRCA2-27673TH
• Product Overview: Recombinant fragment corresponding to amino acids 3319-3418 of Human BRCA2, with a proprietary tag; predicted Mwt 36.63kDa incusive of tag.

Specification

• Description: Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
• Protein length: 100 amino acids
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: SPQMTPFKKFNEISLLESNSIADEE LALINTQALLSGSTGEKQFISVSES TRTAPTSSEDYLRLKRRCTTSLIKE QESSQASTEECEKNKQDTITTKKYI
• Sequence Similarities: Contains 8 BRCA2 repeats.

Gene Information

• Gene Name: BRCA2 breast cancer 2, early onset [ Homo sapiens ]
• Official Symbol: BRCA2
• Synonyms: BRCA2; breast cancer 2, early onset; FACD, FANCD, FANCD1, Fanconi anemia, complementation group D1; breast cancer type 2 susceptibility protein; BRCA1/BRCA2 containing complex; subunit 2; BRCC2; FAD; FAD1
• Gene ID: 675
• mRNA Refseq: NM_000059
• Protein Refseq: NP_000050
• MIM: 600185
• Uniprot ID: P51587
• Chromosome Location: 13q12-q13
• Pathway: DNA Repair, organism-specific biosystem; Double-Strand Break Repair, organism-specific biosystem; FOXM1 transcription factor network, organism-specific biosystem; Fanconi Anemia pathway, organism-specific biosystem; Fanconi anemia pathway, organism-specific biosystem
• Function: DNA binding; H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; gamma-tubulin binding; NOT histone acetyltransferase activity