Recombinant Human CASP4

• Cat.No.: CASP4-26607TH
• Product Overview: Recombinant full length protein (Human)

Specification

• Description: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
• Source: E. coli
• Tissue specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
• Biological activity: 5000 units/mg.
• Form: Lyophilised:Reconstitute to 1 unit per μl in PBS containing 15% glycerol. Aliquot and store immediately at -80°C.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 15% Glycerol, PBS
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase C14A family.Contains 1 CARD domain.

Gene Information

• Gene Name: CASP4 caspase 4, apoptosis-related cysteine peptidase [ Homo sapiens ]
• Official Symbol: CASP4
• Synonyms: CASP4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis related cysteine protease; caspase-4; ICE(rel)II; ICH 2; TX
• Gene ID: 837
• mRNA Refseq: NM_001225
• Protein Refseq: NP_001216
• MIM: 602664
• Uniprot ID: P49662
• Chromosome Location: 11q22.2-q22.3
• Pathway: Apoptosis, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NOD1/2 Signaling Pathway, organism-specific biosystem
• Function: cysteine-type endopeptidase activity; peptidase activity