Recombinant Human SMAD Family Member 5, GST-tagged

• Cat.No.: SMAD5-1493H
• Product Overview: Recombinant full-length human SMAD5 was expressed inE. colicells using an N-terminal GST tag. MW = 82 kDa.

Specification

• Cat. No.: SMAD5-1493H
• Description: SMAD5 is a member of the SMAD family and mediates signaling by the transforming growth factor-beta (TGFβ) superfamily and related ligands. SMAD5 plays a critical role in the signaling pathway by which TGFβ inhibits the proliferation of human hematopoietic progenitor cells. SMAD5 is up-regulated in gastric epithelial cells during the infection of the pathogen Helicobacter pylori and it mediates apoptosis of gastric epithelial cells induced by H. pylori infection. In mature human B cells, bone morphogenetic protein 6 (BMP-6) inhibits cell growth and rapidly induces phosphorylation of SMADs 5 and 8.
• Source: E. coli.
• Sequence: Full-length.
• Applications: Kinase Assay, Western Blot.
• Storage And Stability: Store product at -70℃. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: SMAD5 SMAD family member 5 [ Homo sapiens ]
• Synonyms: SMAD5; SMAD family member 5; Dwfc; JV5-1; MADH5; DKFZp781C1895; DKFZp781O1323; MAD homolog 5; SMA- and MAD-related protein 5; SMAD, mothers against DPP homolog 5; mothers against decapentaplegic homolog 5; MAD, mothers against decapentaplegic homolog 5; mothers against decapentaplegic, drosophila, homolog of, 5; MAD, mothers against decapentaplegic homolog 5 (Drosophila); SMAD, mothers against DPP homolog 5 (Drosophila); Mothers against DPP homolog 5; SMAD 5; Smad5; hSmad5; mothers against decapentaplegic, drosophila, homolog of, 5
• Gene ID: 4090
• mRNA Refseq: NM_001001419
• Protein Refseq: NP_001001419
• MIM: 603110
• UniProt ID: Q99717
• Chromosome Location: 5q31
• Pathway: TGF-beta signaling pathway
• Function: protein binding; receptor signaling protein activity; transcription activator activity; transcription factor activity; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity