"CDKN2A" Related Products

Expand
Expand
Expand

Recombinant Human CDKN2A

Cat.No.: CDKN2A-27912TH
Product Overview: Recombinant full length human CDKN2A/p16INK4a; amino acids 1-156, 16.5 kDa.
Description: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Source: E. coli
Form: Lyophilised:Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 1.0mM PBS, 1.0mM DTT, pH 7.2
Storage: Store at -20°C. Stable for 12 months at -20°C
Sequences of amino acids: MEPAAGSSME PSADWLATAA ARGRVEEVRA LLEAGALPNA PNSYGRRPIQ VMMMGSARVA ELLLLHGAEP NCADPATLTR PVHDAAREGF LDTLVVLHRA GARLDVRDAW GRLPVDLAEE LGHRDVARYL RAAAGGTRGS NHARIDAAEG PSDIPD
Gene Name: CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) [ Homo sapiens ]
Official Symbol: CDKN2A
Synonyms: CDKN2A; cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); CDKN2, MLM; cyclin-dependent kinase inhibitor 2A; ARF; CDK4I; CMM2; INK4; INK4a; MTS1; p14; p16; p16INK4a; p19; p19Arf;
Gene ID: 1029
mRNA Refseq: NM_000077
Protein Refseq: NP_000068
MIM: 600160
Uniprot ID: P42771
Chromosome Location: 9p21
Pathway: Apoptosis, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Cell cycle, organism-specific biosystem;
Function: DNA binding; MDM2 binding; NF-kappaB binding; cyclin-dependent protein kinase inhibitor activity; p53 binding;

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information


Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.