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Recombinant Human Dicarbonyl/L-xylulose Reductase, His-tagged

Cat. No.: DCXR-2726H
Product Overview: Recombinant human DCXR, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW =28 kDa (264aa), confirmed by MALDI-TOF.
Description: Dicarbonyl/L-xylulose reductase, also known as DCXR, is an enzyme responsible for the metabolism ofxylulose, converting it into xylitol. DCXR was expressed at low levels and was localized predominantly in the cytoplasmic membrane. In contrast, in virtually all grades of early-stage prostate cancer and in all chemohormonally treated cases, DCXR was strikingly overexpressed and was localized predominantly in the cytoplasm and nucleus.
Source: E.coli.
Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC
Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% glycerol, 50mM NaCl.
Purity: > 95% by SDS – PAGE.
Concentration: 0.5mg/ml (determined by Bradford assay).
Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Gene Name: DCXR dicarbonyl/L-xylulose reductase [ Homo sapiens ]
Synonyms: DCXR; dicarbonyl/L-xylulose reductase; DCR; HCR2; P34H; HCRII; KIDCR; SDR20C1; L-xylulose reductase; XR; carbonyl reductase II; human carbonyl reductase 2; sperm surface protein P34H; kidney dicarbonyl reductase; short chain dehydrogenase/reductase family 20C, member 1; EC 1.1.1.10
Gene ID: 51181
mRNA Refseq: NM_016286
Protein Refseq: NP_057370
MIM: 608347
UniProt ID: Q7Z4W1
Chromosome Location: 17q25.3
Pathway: Metabolic pathways; Pentose and glucuronate interconversions
Function: L-xylulose reductase (NADP+) activity; binding; oxidoreductase activity, acting on CH-OH group of donors

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