Recombinant Human COL4A3, His-tagged COL4A3-27222TH

Recombinant Human COL4A3, His-tagged


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Recombinant Human COL4A3, His-tagged

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Cat.No. : COL4A3-27222TH
Product Overview : Recombinant Fragment of Human COL4A3, created by removal of most of the epitope-less triplehelical collagenous region ; produced from Sf9 insect cells fused to a hexa-histidine purification tag, 43,591 Dalton.
Description : Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Conjugation : HIS
Tissue specificity : Alpha 3 and alpha 4 type IV collagens are colocalized and present in kidney, eye, basement membranes of lens capsule, cochlea, lung, skeletal muscle, aorta, synaptic fibers, fetal kidney and fetal lung. PubMed:8083201 reports similar levels of expression
Form : Liquid
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the type IV collagen family.Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain.
Gene Name : COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) [ Homo sapiens ]
Official Symbol : COL4A3
Synonyms : COL4A3; collagen, type IV, alpha 3 (Goodpasture antigen); collagen alpha-3(IV) chain; tumstatin;
Gene ID : 1285
mRNA Refseq : NM_000091
Protein Refseq : NP_000082
MIM : 120070
Uniprot ID : Q01955
Chromosome Location : 2q36-q37
Pathway : Axon guidance, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Integrin cell surface interactions, organism-specific biosystem; Integrins in angiogenesis, organism-specific biosystem; NCAM signaling for neurite out-growth, organism-specific biosystem;
Function : extracellular matrix structural constituent; integrin binding; integrin binding; metalloendopeptidase inhibitor activity; protein binding;

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