Recombinant Human CTGF

• Cat.No.: CTGF-28023TH
• Product Overview: Recombinant fragment, corresponding to amino acids 253-350 of Human CTGF, a 11.2 kDa protein of 98 amino acid residues which exerts full heparin binding, cell adhesion, and mitogenic CTGF activity.

Specification

• Description: The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
• Source: E. coli
• Tissue specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.
• Biological activity: Biological Activity : Determined by the dose-dependent stimulation of the proliferation of HUVEC cells. The expected ED50 for this effect is 1.0-2.0 μg/ml.
• Form: Lyophilised
• Purity: >95% by SDS-PAGE
• Storage buffer: Spin down vial and reconstitute in distilled water for a concentration of 0.1 - 1.0 mg/ml.
• Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
• Sequences of amino acids: MGKKCIRTPK ISKPIKFELS GCTSMKTYRA KFCGVCTDGR CCTPHRTTTL PVEFKCPDGE VMKKNMMFIK TCACHYNCPG DNDIFESLYY RKMYGDMA
• Sequence Similarities: Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain.

Gene Information

• Gene Name: CTGF connective tissue growth factor [ Homo sapiens ]
• Official Symbol: CTGF
• Synonyms: CTGF; connective tissue growth factor; CCN2; IGFBP8
• Gene ID: 1490
• mRNA Refseq: NM_001901
• Protein Refseq: NP_001892
• MIM: 121009
• Uniprot ID: P29279
• Chromosome Location: 6q23.2
• Pathway: Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem; Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem; TGF-beta receptor signaling, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem
• Function: fibronectin binding; growth factor activity; heparin binding; insulin-like growth factor binding