Cat.No.:	CXCL14-28059TH
Product Overview:	Recombinant Human BRAK, a 9.4 kDa protein containing 77 amino acid residues.
Description:	This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
Source:	E. coli
Tissue specificity:	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. N
Biological activity:	Biological Activity : Determined by its ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml.
Form:	Lyophilised
Storage:	The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
Sequences of amino acids:	SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE
Sequence Similarities:	Belongs to the intercrine alpha (chemokine CxC) family.

Gene Name:	CXCL14 chemokine (C-X-C motif) ligand 14 [ Homo sapiens ]
Official Symbol:	CXCL14
Synonyms:	CXCL14; chemokine (C-X-C motif) ligand 14; SCYB14, small inducible cytokine subfamily B (Cys X Cys), member 14 (BRAK); C-X-C motif chemokine 14; BMAC; bolekine; BRAK; breast and kidney; Kec; KS1; MIP 2g; NJAC;
Gene ID:	9547
mRNA Refseq:	NM_004887
Protein Refseq:	NP_004878
MIM:	604186
Uniprot ID:	O95715
Chromosome Location:	5q31
Pathway:	Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Senescence and Autophagy, organism-specific biosystem;
Function:	chemokine activity;

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