||Recombinant Human BRAK, a 9.4 kDa protein containing 77 amino acid residues.
||This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
||Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. N
||Biological Activity : Determined by its ability to chemoattract activated monocytes using a concentration range of 1.0-10.0 ng/ml.
||The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
|Sequences of amino acids:
||SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE
||Belongs to the intercrine alpha (chemokine CxC) family.