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Recombinant Human CYLD

Cat.No. : CYLD-27021TH
Product Overview : Recombinant fragment of Human CYLD with N terminal proprietary tag, 36.63kDa.
  • Specification
  • Gene Information
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Description : This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Detected in fetal brain, testis, and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : QNMELFAVLCIETSHYVAFVKYGKD DSAWLFFDSMADRDGGQNGFNIPQV TPCPEVGEYLKMSLEDLHSLDSRRI QGCARRLLCDAYMCMYQSPTMSLYK
Sequence Similarities : Belongs to the peptidase C67 family.Contains 3 CAP-Gly domains.
Gene Name : CYLD cylindromatosis (turban tumor syndrome) [ Homo sapiens ]
Official Symbol : CYLD
Synonyms : CYLD; cylindromatosis (turban tumor syndrome); CYLD1; ubiquitin carboxyl-terminal hydrolase CYLD; KIAA0849; ubiquitin specific peptidase like 2; USPL2;
Gene ID : 1540
mRNA Refseq : NM_015247
Protein Refseq : NP_056062
MIM : 605018
Uniprot ID : Q9NQC7
Chromosome Location : 16q12-q13
Pathway : Canonical NF-kappaB pathway, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NOD1/2 Signaling Pathway, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem;
Function : cysteine-type peptidase activity; metal ion binding; peptidase activity; proline-rich region binding; protein binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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