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Recombinant Human CYP2A6

Cat.No. : CYP2A6-27019TH
Product Overview : Recombinant fragment corresponding to amino acids 395-494 of Human Cytochrome P450 2A6 with an N terminal proprietary tag; Predicted MWt 36.63 kDa inclusive of tag.
  • Specification
  • Gene Information
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Description : This gene, CYP2A6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6.
Protein length : 100 amino acids
Molecular Weight : 36.630kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Liver.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : LGSVLRDPSFFSNPQDFNPQHFLNE KGQFKKSDAFVPFSIGKRNCFGEGL ARMELFLFFTTVMQNFRLKSSQSPK DIDVSPKHVGFATIPRNYTMSFLPR
Sequence Similarities : Belongs to the cytochrome P450 family.
Gene Name : CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 [ Homo sapiens ]
Official Symbol : CYP2A6
Synonyms : CYP2A6; cytochrome P450, family 2, subfamily A, polypeptide 6; CYP2A3, cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 6; cytochrome P450 2A6; CPA6; CYP2A;
Gene ID : 1548
mRNA Refseq : NM_000762
Protein Refseq : NP_000753
Uniprot ID : P11509
Chromosome Location : 19q13.2
Pathway : Biological oxidations, organism-specific biosystem; Caffeine metabolism, organism-specific biosystem; Caffeine metabolism, conserved biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem;
Function : aromatase activity; coumarin 7-hydroxylase activity; electron carrier activity; enzyme binding; heme binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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