Recombinant Human DCXR, His-tagged

• Cat.No.: DCXR-26175TH
• Product Overview: Recombinant full length Human DCXR (amino acids 1-244) with N terminal His tag; 264 amino acids, 28kDa.

Specification

• Description: The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.
• Protein length: 244 amino acids
• Conjugation: HIS
• Molecular Weight: 28.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Highly expressed in kidney, liver and epididymis. In the epididymis, it is mainly expressed in the proximal and distal sections of the corpus region. Weakly or not expressed in brain, lung, heart, spleen and testis.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 0.02% DTT, 0.29% Sodium chloride, 20% Glycerol
• Storage: Store at -20°C (dessicate conditions).
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MELFLAGRRV LVTGAGKGIG RGTVQALHAT GARVVAVSRT QADLDSLVRE CPGIEPVCVD LGDWEATERA LGSVGPVDLL VNNAAVALLQ PFLEVTKEAF DRSFEVNLRA VIQVSQIVAR GLIARGVPGA IVNVSSQCSQ RAVTNHSVYC STKGALDMLT KVMALELGPH KIRVNAVNPT VVMTSMGQAT WSDPHKAKTM LNRIPLGKFA EVEHVVNAIL FLLSDRSGMT TGSTLPVEGG FWAC
• Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Gene Information

• Gene Name: DCXR dicarbonyl/L-xylulose reductase [ Homo sapiens ]
• Official Symbol: DCXR
• Synonyms: DCXR; dicarbonyl/L-xylulose reductase; L-xylulose reductase; DCR; KIDCR; SDR20C1; short chain dehydrogenase/reductase family 20C; member 1
• Gene ID: 51181
• mRNA Refseq: NM_001195218
• Protein Refseq: NP_001182147
• MIM: 608347
• Uniprot ID: Q7Z4W1
• Chromosome Location: 17q25.3
• Pathway: Metabolic pathways, organism-specific biosystem; Pentose and glucuronate interconversions, organism-specific biosystem; Pentose and glucuronate interconversions, conserved biosystem
• Function: L-xylulose reductase (NADP+) activity; nucleotide binding; oxidoreductase activity, acting on CH-OH group of donors