Recombinant Human DDC

• Cat.No.: DDC-28085TH
• Product Overview: Recombinant full length protein (Human)

Specification

• Description: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the group II decarboxylase family.

Gene Information

• Gene Name: DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) [ Homo sapiens ]
• Official Symbol: DDC
• Synonyms: DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); aromatic-L-amino-acid decarboxylase; AADC
• Gene ID: 1644
• mRNA Refseq: NM_001242889
• Protein Refseq: NP_001229818
• MIM: 107930
• Uniprot ID: P20711
• Chromosome Location: 7p11
• Pathway: Amine-derived hormones, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Catecholamine biosynthesis, organism-specific biosystem; Catecholamine biosynthesis, tyrosine => dopamine =>
• Function: amino acid binding; aromatic-L-amino-acid decarboxylase activity; aromatic-L-amino-acid decarboxylase activity; lyase activity; protein binding