Recombinant Human DPP3
Cat.No. : | DPP3-28433TH |
Product Overview : | Recombinant full length Human DPP3 with N terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, 109 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternate transcriptional splice variants have been characterized. |
Biological activity : | Specific Activity: 425 pmol/min/µg. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 50% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the peptidase M49 family. |
Gene Name : | DPP3 dipeptidyl-peptidase 3 [ Homo sapiens ] |
Official Symbol : | DPP3 |
Synonyms : | DPP3; dipeptidyl-peptidase 3; dipeptidylpeptidase 3 , dipeptidylpeptidase III; dipeptidyl peptidase 3; |
Gene ID : | 10072 |
mRNA Refseq : | NM_130443 |
Protein Refseq : | NP_569710 |
MIM : | 606818 |
Uniprot ID : | Q9NY33 |
Chromosome Location : | 11q12-q13.1 |
Function : | aminopeptidase activity; dipeptidyl-peptidase activity; metal ion binding; metallopeptidase activity; peptidase activity; |
Products Types
◆ Recombinant Protein | ||
Dpp3-2640M | Recombinant Mouse Dpp3 Protein, Myc/DDK-tagged | +Inquiry |
DPP3-1601R | Recombinant Rat DPP3 Protein, His (Fc)-Avi-tagged | +Inquiry |
DPP3-2841H | Recombinant Human DPP3 Protein, GST-tagged | +Inquiry |
Dpp3-1054M | Recombinant Mouse Dpp3 protein, His & T7-tagged | +Inquiry |
DPP3-1942R | Recombinant Rat DPP3 Protein | +Inquiry |
◆ Lysates | ||
DPP3-6832HCL | Recombinant Human DPP3 293 Cell Lysate | +Inquiry |
DPP3-6831HCL | Recombinant Human DPP3 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1717 | DPP3 Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionDPP3 is involved in the final stages of protein catabolism, breaking down small peptides into amino acids, which can then be reused in protein synthesis or participate in various metabolic pathways.
DPP3 expression varies among tissues, with higher levels in the heart, liver, and kidneys. Its expression is regulated by various factors, including hormonal and metabolic cues.
Some inhibitors targeting DPP3 have been identified, though their therapeutic implications are still under exploration. Inhibiting DPP3 might be beneficial in conditions where its overactivity contributes to disease pathology.
DPP3 is known to metabolize certain drugs, affecting their bioavailability and efficacy. Understanding DPP3's role in drug metabolism can help in drug design and dosage determination.
Dysregulation of DPP3 has been associated with certain cancers and inflammatory conditions. However, the exact pathological role of DPP3 in these conditions is still under investigation.
The DPP3 gene encodes dipeptidyl peptidase III (DPP3), an intracellular zinc-dependent enzyme. Its primary function is to cleave dipeptides from the N-termini of polypeptides.
Unlike other dipeptidyl peptidases, DPP3 has a broader substrate specificity, cleaving a variety of dipeptidyl-2-arylamide substrates and playing roles in multiple physiological processes.
Customer Reviews (3)
Write a reviewFast delivery, great packaging.
No issues, worked great.
Quality better than expected.
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