Recombinant Human DTNBP1, His-tagged

• Cat.No.: DTNBP1-26932TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-351 of Human Dysbindin with an N terminal His tag. Predicted mwt: 40 kDa

Specification

• Description: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitution with 85 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MLETLRERLLSVQQDFTSGLKTLSDKSREAKVKSKPRTVP FLPKYSAGLELLSRYEDTWAALHRRAKDCASAGELVDS EVVMLSAHWEKKKTSLVELQEQLQQLPALIADLESMTA NLTHLEASFEEVENNLLHLEDLCGQCELERCKHMQSQQ LENYKKNKRKELETFKAELDAEHAQKVLEMEHTQQMKLKE RQKFFEEAFQQDMEQYLSTGYLQIAERREPIGSMSSME VNVDMLEQMDLMDISDQEALDVFLNSGGEENTVLSPAL GPESSTCQNEITLQVPNPSELRAKPPSSSSTCTDSATR DISEGGESPVVQSDEEEVQVDTALATSHTDREATPDGG EDSDS

Gene Information

• Gene Name: DTNBP1 dystrobrevin binding protein 1 [ Homo sapiens ]
• Official Symbol: DTNBP1
• Synonyms: DTNBP1; dystrobrevin binding protein 1; dysbindin; DBND; Dysbindin; HPS7; My031
• Gene ID: 84062
• mRNA Refseq: NM_032122
• Protein Refseq: NP_115498
• MIM: 607145
• Uniprot ID: Q96EV8
• Chromosome Location: 6p22.3
• Pathway: Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem
• Function: protein binding