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Recombinant Human E2F2

Cat.No. : E2F2-27376TH
Product Overview : Recombinant full length Human E2F2 with N terminal proprietary tag; Predicted MWt 35.24 kDa.
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  • Gene Information
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Description : The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.
Protein length : 83 amino acids
Molecular Weight : 35.240kDa inclusive of tags
Source : Wheat germ
Tissue specificity : Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MESRSVAQAGVQWPDLGSLQPLPPR FKRFFCLSLQSSWDYRHAPPRPANF VFLVETGFCHVSQAGLELLTSSDPP PRPPKVLR
Sequence Similarities : Belongs to the E2F/DP family.
Gene Name : E2F2 E2F transcription factor 2 [ Homo sapiens ]
Official Symbol : E2F2
Synonyms : E2F2; E2F transcription factor 2; transcription factor E2F2; E2F 2;
Gene ID : 1870
mRNA Refseq : NM_004091
Protein Refseq : NP_004082
MIM : 600426
Uniprot ID : Q14209
Chromosome Location : 1p36
Pathway : Assembly of the pre-replicative complex, organism-specific biosystem; Association of licensing factors with the pre-replicative complex, organism-specific biosystem; Bladder cancer, organism-specific biosystem; Bladder cancer, conserved biosystem; CDC6 association with the ORC:origin complex, organism-specific biosystem;
Function : DNA binding; core promoter binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription factor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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