"EIF4E" Related Products

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Recombinant Human EIF4E protein, His-tagged

Cat.No.: EIF4E-26389TH
Product Overview: Recombinant Human EIF4E(1-217aa) fused with His tag at N-terminal was expressed in E. coli.
Description: EIF4E, a member of eukaryotic initiation factor 4 families, modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. This protein recognizes and binds to the 7 methyl GTP cap structure of eukaryotic mRNAs, thereby mediating the initiation of translation. It facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.
Source: E. coli
Species: Human
Tag: His
Form: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 10% Glycerol, 1mM DTT
Molecular Mass: 27.2 kDa(237aa), confirmed by MALDI-TOF
AA Sequence: MGSSHHHHHH SSGLVPRGSH MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL RLISKFDTVEDFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKGDKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV
Purity: > 85% by SDS - PAGE
Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
Concentration: 0.5 mg/ml (determined by Bradford assay)
Gene Name: EIF4E eukaryotic translation initiation factor 4E [ Homo sapiens ]
Official Symbol: EIF4E
Synonyms: EIF4E; eukaryotic translation initiation factor 4E; EIF4EL1, EIF4F; EIF4E1; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; eukaryotic translation initiation factor 4E-like 1; CBP; EIF4F; EIF4EL1; MGC111573;
Gene ID: 1977
mRNA Refseq: NM_001968
Protein Refseq: NP_001959
MIM: 133440
UniProt ID: P06730
Chromosome Location: 4q21-q25
Pathway: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem; Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem; Cap-dependent Translation Initiation, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Deadenylation of mRNA, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem;
Function: RNA cap binding; protein binding; translation initiation factor activity;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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