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Recombinant Human ENG

Cat.No.: ENG-27806TH
Product Overview: Recombinant fragment, corresponding to amino acids 26-176 of Human CD105
Description: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source: E. coli
Tissue specificity: Endoglin is restricted to endothelial cells in all tissues except bone marrow.
Form: Liquid
Purity: Purified via GST Tag
Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Gene Name: ENG endoglin [ Homo sapiens ]
Official Symbol: ENG
Synonyms: ENG; endoglin; ORW, ORW1, Osler Rendu Weber syndrome 1; CD105; END; HHT1;
Gene ID: 2022
mRNA Refseq: NM_000118
Protein Refseq: NP_000109
MIM: 131195
Uniprot ID: P17813
Chromosome Location: 9q33-q34.1
Pathway: HIF-1-alpha transcription factor network, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function: activin binding; galactose binding; glycosaminoglycan binding; glycosaminoglycan binding; protein binding;

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