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Recombinant Human EPHB4

Cat.No.: EPHB4-28623TH
Product Overview: Recombinant fragment, corresponding to cytoplamsic domain amino acids 561-987 of Human Eph receptor B4 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system, MWt 50kDa.
Description: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development.
Tissue specificity: Abundantly expressed in placenta and in a range of primary tissues and malignant cell lines. Expressed in fetal, but not adult, brain, and in primitive and myeloid, but not lymphoid, hematopoietic cells.
Biological activity: The Specific activity of EPHB4-28623TH was determined to be 410 nmol/min/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.Contains 2 fibronectin type-III domains.Contains 1 protein kinase domain.Contains 1 SAM (sterile alpha motif) domain.
Gene Name: EPHB4 EPH receptor B4 [ Homo sapiens ]
Official Symbol: EPHB4
Synonyms: EPHB4; EPH receptor B4; EphB4 , HTK; ephrin type-B receptor 4; Tyro11;
Gene ID: 2050
mRNA Refseq: NM_004444
Protein Refseq: NP_004435
MIM: 600011
Uniprot ID: P54760
Chromosome Location: 7q22
Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; EPHB forward signaling, organism-specific biosystem; Ephrin B reverse signaling, organism-specific biosystem; EphrinB-EPHB pathway, organism-specific biosystem;
Function: ATP binding; ephrin receptor activity; ephrin receptor activity; nucleotide binding; protein binding;

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