"BCL2L2" Related Products

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Recombinant Human BCL2-Like 2

Cat. No.: BCL2L2-1588H
Description: Bcl-w is a member of the Bcl-2 family of proteins that regulates outer mitochondrial membrane permeability.1, 2 Bcl-w is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-w is required for normal sperm maturation. Natural Bcl-w contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-w missing the mitochondrial targeting sequence maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-w appears to be through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence.
Source: E. coli.
State Of Matter: Solution.
Purity: >95% by SDS Page and analyzed by silver stain.
Molecular Weight: The predicted molecular weight of Recombinant Human Bcl-W (minus c-terminal) is Mr 18 kDa.
Storage: -20°C to -70°C.
Gene Name: BCL2L2 BCL2-like 2 [ Homo sapiens ]
Synonyms: BCL2-like 2; BCLW; BCL-W; KIAA0271; BCL2L2; BCL2-like 2 protein; apoptosis regulator BCL-W; Bcl2-L-2; Apoptosis regulator Bcl-W
Gene ID: 599
mRNA Refseq: NM_004050
Protein Refseq: NP_004041
MIM: 601931
UniProt ID: Q92843
Chromosome Location: 14q11.2-q12
Function: protein binding

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