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Recombinant Human ERCC3

Cat.No. : ERCC3-30702TH
Product Overview : Recombinant full length Human XPB with a N terminal proprietary tag; predicted MW: 112.09 kDa inclusive of tag. P19447,
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Description : ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.
Protein length : 782 amino acids
Molecular Weight : 112.090kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPS AAGKQVDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAP DGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTA YSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCT VSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLR NSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQG KSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEEL QKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQ EKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKR CLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKP IGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMIL DEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDL NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYR EYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIV FADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNP KINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRL GRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFL VDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAAT DLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYME YHSSRSKAPSKHVHPLFKRFRK
Sequence Similarities : Belongs to the helicase family. RAD25/XPB subfamily.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.
Gene Name : ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) [ Homo sapiens ]
Official Symbol : ERCC3
Synonyms : ERCC3; excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing); TFIIH basal transcription factor complex helicase XPB subunit; BTF2; GTF2H; RAD25; TFIIH; XPB;
Gene ID : 2071
mRNA Refseq : NM_000122
Protein Refseq : NP_000113
MIM : 133510
Uniprot ID : P19447
Chromosome Location : 2q21
Pathway : Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; DNA Repair, organism-specific biosystem; Dual incision reaction in GG-NER, organism-specific biosystem; Dual incision reaction in TC-NER, organism-specific biosystem;
Function : 3-5 DNA helicase activity; 3-5 DNA helicase activity; ATP binding; ATP-dependent DNA helicase activity; ATPase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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