Recombinant Human FAP

• Cat.No.: FAP-28896TH
• Product Overview: Recombinant fragment of Human Fibroblast activation protein, alpha (amino acids 559-760) with proprietary tag; 202aa (without tag), 48kDa.

Specification

• Description: The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.
• Protein length: 202 amino acids
• Molecular Weight: 48.000kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Fibroblast specific.
• Form: Liquid
• Storage buffer: pH: 7.50Constituents:20% Glycerol, Tris acetate, 0.03% EDTA
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: SYLASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD
• Sequence Similarities: Belongs to the peptidase S9B family.

Gene Information

• Gene Name: FAP fibroblast activation protein, alpha [ Homo sapiens ]
• Official Symbol: FAP
• Synonyms: FAP; fibroblast activation protein, alpha; seprase; DPPIV
• Gene ID: 2191
• mRNA Refseq: NM_004460
• Protein Refseq: NP_004451
• MIM: 600403
• Uniprot ID: Q12884
• Chromosome Location: 2q23
• Function: dipeptidyl-peptidase activity; metalloendopeptidase activity; peptidase activity; protein binding; protein dimerization activity