||Recombinant fragment, corresponding to amino acids 520-1043 of Human FBXO18 with N terminal His tag; 524 amino acids, 61kDa.
||This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.
||Lyophilised:Reconstitute with 104 μl aqua dest.
||Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
||Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
|Sequences of amino acids:
||GRKYQSKKKLNLFKLTPFMVNSVLAEGKGGFIRAKLVCKT LENFFASADEELTIDHVPIWCKNSQGQRVMVEQSEKLN GVLEASRLWDNMRKLGECTEEAHQMTHDGYLKLWQLSKPS LASFDAIFVDEAQDCTPAIMNIVLSQPCGKIFVGDPHQ QIYTFRGAVNALFTVPHTHVFYLTQSFRFGVEIAYVGA TILDVCKRVRKKTLVGGNHQSGIRGDAKGQVALLSRTNAN VFDEAVRVTEGEFPSRIHLIGGIKSFGLDRIIDIWILL QPEEERRKQNLVIKDKFIRRWVHKEGFSGFKRYVTAAE DKELEAKIAVVEKYNIRIPELVQRIEKCHIEDLDFAEYIL GTVHKAKGLEFDTVHVLDDFVKVPCARHNLPQLPHFRV ESFSEDEWNLLYVAVTRAKKRLIMTKSLENILTLAGEY FLQAELTSNVLKTGVVRCCVGQCNNAIPVDTVLTMKKLPI TYSNRKENKGGYLCHSCAEQRIGPLAFLTASPEQVRAM ERTVENIVLPRHEALLFLVF