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Recombinant Human FST

Cat.No.: FST-28106TH
Product Overview: Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids including 36 cysteine residues.
Description: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release.The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA.In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.
Source: E. coli
Tissue specificity: Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.
Form: Lyophilised:Reconstitute in water to a concentration of 0.1-1.0 μg/μl.
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 75mM Sodium chloride, 10mM Sodium phosphate, pH 7.5
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities: Contains 3 follistatin-like domains.Contains 3 Kazal-like domains.Contains 1 TB (TGF-beta binding) domain.
Gene Name: FST follistatin [ Homo sapiens ]
Official Symbol: FST
Synonyms: FST; follistatin; FS;
Gene ID: 10468
mRNA Refseq: NM_006350
Protein Refseq: NP_006341
MIM: 136470
Uniprot ID: P19883
Chromosome Location: 5q11.2
Pathway: BMP receptor signaling, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem;
Function: activin binding; heparan sulfate proteoglycan binding; protein binding; signal transducer activity;

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