Recombinant Human GAD2

• Cat.No.: GAD2-26072TH
• Product Overview: Recombinant full length Human GAD65 with N terminal proprietary tag; Predicted MWt 90.42 kDa.

Specification

• Description: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein.
• Protein length: 585 amino acids
• Molecular Weight: 90.420kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGI GNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQK PCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNIL LQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNL EEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWL TSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGS GDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLI AFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIP SDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVAD ICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSV TWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQD KHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFE AHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWY IPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVS YQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL
• Sequence Similarities: Belongs to the group II decarboxylase family.

Gene Information

• Gene Name: GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) [ Homo sapiens ]
• Official Symbol: GAD2
• Synonyms: GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65
• Gene ID: 2572
• mRNA Refseq: NM_000818
• Protein Refseq: NP_000809
• MIM: 138275
• Uniprot ID: Q05329
• Chromosome Location: 10p13-p11.2
• Pathway: Alanine and aspartate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Butanoate metabolism, organism-specific biosystem
• Function: carboxy-lyase activity; glutamate decarboxylase activity; lyase activity; protein binding; pyridoxal phosphate binding