Recombinant Human GAD2
Cat.No. : | GAD2-26072TH |
Product Overview : | Recombinant full length Human GAD65 with N terminal proprietary tag; Predicted MWt 90.42 kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. |
Protein length : | 585 amino acids |
Molecular Weight : | 90.420kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGI GNKLCALLYGDAEKPAESGGSQPPRAAARKAACACDQK PCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNIL LQYVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNL EEILMHCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWL TSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGS GDGIFSPGGAISNMYAMMIARFKMFPEVKEKGMAALPRLI AFTSEHSHFSLKKGAAALGIGTDSVILIKCDERGKMIP SDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVAD ICKKYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSV TWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQD KHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFE AHVDKCLELAEYLYNIIKNREGYEMVFDGKPQHTNVCFWY IPPSLRTLEDNEERMSRLSKVAPVIKARMMEYGTTMVS YQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL |
Sequence Similarities : | Belongs to the group II decarboxylase family. |
Gene Name : | GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) [ Homo sapiens ] |
Official Symbol : | GAD2 |
Synonyms : | GAD2; glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 2 (pancreatic islets and brain, 65kD); glutamate decarboxylase 2; GAD65; |
Gene ID : | 2572 |
mRNA Refseq : | NM_000818 |
Protein Refseq : | NP_000809 |
MIM : | 138275 |
Uniprot ID : | Q05329 |
Chromosome Location : | 10p13-p11.2 |
Pathway : | Alanine and aspartate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Butanoate metabolism, organism-specific biosystem; |
Function : | carboxy-lyase activity; glutamate decarboxylase activity; lyase activity; protein binding; pyridoxal phosphate binding; |
Products Types
◆ Recombinant Protein | ||
GAD2-1303M | Recombinant Mouse GAD2 protein(Met1-Leu585) | +Inquiry |
GAD2-1618R | Recombinant Rhesus Macaque GAD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAD2-9170H | Recombinant Human GAD2 Protein, N-His tagged | +Inquiry |
GAD2-2114R | Recombinant Rat GAD2 Protein, His (Fc)-Avi-tagged | +Inquiry |
GAD2-4655H | Recombinant Human GAD2 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
GAD2-001MCL | Recombinant Mouse GAD2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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