Cat. No.:	Cx3cl1-127M
Description:	Fractalkine (FKN) is a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium that mediates attachment and firm adhesion of T cells, monocytes and NK cells. FKN plays an important proinflammatory role in rheumatoid arthritis (RA) pathogenesis as characterized by induction of synovial angiogenesis, chemotaxis, activation of monocytes and T cells as well as the stimulation of proliferation and synthesis of matrix degrading enzymes (matrix metalloproteinases, MMP) in synovial fibroblasts. Fractalkine thus may represent a novel target molecule for therapeutic intervention in RA.3 FKN is also an essential biomarker for predicting the prognosis of patients with colorectal cancer (CRC).
Source:	Sf 21 Insect Cells.
State Of Matter:	Lyophilized.
Purity:	>97% by SDS Page and analyzed by silver stain.
Endotoxin:	<1.0 EU/µg as determined by the LAL method.
Molecular Weight:	The predicted molecular weight of Recombinant Mouse Fractalkine is Mr 34 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90 kDa.
Storage And Stability:	This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Gene Name:	Cx3cl1 chemokine (C-X3-C motif) ligand 1 [ Mus musculus ]
Synonyms:	chemokine (C-X3-C motif) ligand 1; CX3C; Cxc3; Scyd1; ABCD-3; AB030188; AI848747; D8Bwg0439e; Cx3cl1; fractalkine; neurotactin; small inducible cytokine subfamily D, 1
Gene ID:	20312
mRNA Refseq:	NM_009142
Protein Refseq:	NP_033168
UniProt ID:	O35188
Chromosome Location:	8 46.0 cM
Pathway:	Chemokine signaling pathway; Cytokine-cytokine receptor interaction
Function:	chemokine activity; cytokine activity; protein binding

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