Cat. No. : |
Cx3cl1-127M |
Description : |
Fractalkine (FKN) is a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium that mediates attachment and firm adhesion of T cells, monocytes and NK cells. FKN plays an important proinflammatory role in rheumatoid arthritis (RA) pathogenesis as characterized by induction of synovial angiogenesis, chemotaxis, activation of monocytes and T cells as well as the stimulation of proliferation and synthesis of matrix degrading enzymes (matrix metalloproteinases, MMP) in synovial fibroblasts. Fractalkine thus may represent a novel target molecule for therapeutic intervention in RA.3 FKN is also an essential biomarker for predicting the prognosis of patients with colorectal cancer (CRC). |
Source : |
Sf 21 Insect Cells. |
State Of Matter : |
Lyophilized. |
Purity : |
>97% by SDS Page and analyzed by silver stain. |
Endotoxin : |
<1.0 EU/µg as determined by the LAL method. |
Molecular Weight : |
The predicted molecular weight of Recombinant Mouse Fractalkine is Mr 34 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90 kDa. |
Storage And Stability : |
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |