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Recombinant Human GGCT, His-tagged

Cat.No. : GGCT-28745TH
Product Overview : Recombinant full length Human GGCT with an N terminal His tag; 208 amino acids with tag, Predicted MWt 23.2 kDa.
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  • Gene Information
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Description : The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Protein length : 188 amino acids
Conjugation : HIS
Molecular Weight : 23.200kDa inclusive of tags
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMANSG CKDVTGPDEESFLYFAYGSNLLTER IHLRNPSAAFFCVARLQDFKLDFGN SQGKTSQTWHGGIATIFQSPGDEVW GVVWKMNKSNLNSLDEQEGVKSGMY VVIEVKVATQEGKEITCRSYLMTNY ESAPPSPQYKKIICMGAKENGLPLE YQEKLKAIEPNDYTGKVSEEIEDII KKGETQTL
Gene Name : GGCT gamma-glutamylcyclotransferase [ Homo sapiens ]
Official Symbol : GGCT
Synonyms : GGCT; gamma-glutamylcyclotransferase; C7orf24, chromosome 7 open reading frame 24 , GCTG; CRF21; Ggc; MGC3077;
Gene ID : 79017
mRNA Refseq : NM_001199817
Protein Refseq : NP_001186746
MIM : 137170
Uniprot ID : O75223
Chromosome Location : 7p15-p14
Pathway : Biological oxidations, organism-specific biosystem; Glutathione conjugation, organism-specific biosystem; Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; Glutathione synthesis and recycling, organism-specific biosystem;
Function : gamma-glutamylcyclotransferase activity; gamma-glutamylcyclotransferase activity; protein homodimerization activity; transferase activity, transferring acyl groups;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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