Recombinant Human GLDC GLDC-29067TH

Recombinant Human GLDC

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Recombinant Human GLDC

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Cat.No. : GLDC-29067TH
Product Overview : Recombinant fragment of Human GLDC protein with an N terminal proprietary tag; Predicted MW 36.52 kDa.
Description : Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
Protein length : 99 amino acids
Molecular Weight : 36.520kDa inclusive of tags
Source : Wheat germ
Form : Liquid
Purity : Proprietary Purification
Storage buffer : pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids : AMISIRQEIADIEEG RIDPRVNPLKMSPHS LTCVTSSHWDRPYSR EVAAFPLPFMKPENK FWPTIARIDDIYGDQ HLVCTCPPMEVYESP FSEQKRASS
Sequence Similarities : Belongs to the gcvP family.
Gene Name : GLDC glycine dehydrogenase (decarboxylating) [ Homo sapiens ]
Official Symbol : GLDC
Synonyms : GLDC; glycine dehydrogenase (decarboxylating); glycine dehydrogenase (decarboxylating; glycine decarboxylase, glycine cleavage system protein P); glycine dehydrogenase [decarboxylating], mitochondrial; GCSP; glycine cleavage system protein P; glycine deca
Gene ID : 2731
mRNA Refseq : NM_000170
Protein Refseq : NP_000161
MIM : 238300
Uniprot ID : P23378
Chromosome Location : 9p22
Pathway : Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function : electron carrier activity; glycine dehydrogenase (decarboxylating) activity; lyase activity; oxidoreductase activity; pyridoxal phosphate binding;

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