Recombinant Human GLUL, His-tagged

• Cat.No.: GLUL-27525TH
• Product Overview: Recombinant full length Human Glutamine Synthetase with N-terminal His tag; 393 amino acids, MWt 44.2 kDa.

Specification

• Description: The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is a main source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signaling. This gene is expressed during early fetal stages, and plays an important role in controlling body pH by removing ammonia from circulation. Mutations in this gene are associated with congenital glutamine deficiency. Several alternatively spliced transcript variants have been found for this gene.
• Protein length: 373 amino acids
• Conjugation: HIS
• Molecular Weight: 44.200kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 5mM DTT, 200mM Sodium chloride, 20mM Tris HCl, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMTTSA SSHLNKGIKQVYMSLPQGEKVQAMY IWIDGTGEGLRCKTRTLDSEPKCVE ELPEWNFDGSSTLQSEGSNSDMYLV PAAMFRDPFRKDPNKLVLCEVFKYN RRPAETNLRHTCKRIMDMVSNQHPW FGMEQEYTLMGTDGHPFGWPSNGFP GPQGPYYCGVGADRAYGRDIVEAHY RACLYAGVKIAGTNAEVMPAQWEFQ IGPCEGISMGDHLWVARFILHRVCE DFGVIATFDPKPIPGNWNGAGCHTN FSTKAMREENGLKYIEEAIEKLSKR HQYHIRAYDPKGGLDNARRLTGFHE TSNINDFSAGVANRSASIRIPRTVG QEKKGYFEDRRPSANCDPFSVTEAL IRTCLLNETGDEPFQYKN
• Sequence Similarities: Belongs to the glutamine synthetase family.

Gene Information

• Gene Name: GLUL glutamate-ammonia ligase [ Homo sapiens ]
• Official Symbol: GLUL
• Synonyms: GLUL; glutamate-ammonia ligase; GLNS, glutamate ammonia ligase (glutamine synthase); glutamine synthetase
• Gene ID: 2752
• mRNA Refseq: NM_001033044
• Protein Refseq: NP_001028216
• MIM: 138290
• Uniprot ID: P15104
• Chromosome Location: 1q31
• Pathway: Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Amino acid synthesis and interconversion (transamination), organism-specific biosystem; Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem
• Function: ATP binding; glutamate decarboxylase activity; glutamate-ammonia ligase activity; identical protein binding; ligase activity