Recombinant Human GNMT, His-tagged

• Cat.No.: GNMT-29092TH
• Product Overview: Recombinant full length human GNMT protein, fused to His tag at N terminus; 315 amino acids, 34.9 kDa.

Specification

• Description: The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia).
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Abundant in liver.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD
• Sequence Similarities: Belongs to the glycine N-methyltransferase family.

Gene Information

• Gene Name: GNMT glycine N-methyltransferase [ Homo sapiens ]
• Official Symbol: GNMT
• Synonyms: GNMT; glycine N-methyltransferase
• Gene ID: 27232
• mRNA Refseq: NM_018960
• Protein Refseq: NP_061833
• MIM: 606628
• Uniprot ID: Q14749
• Chromosome Location: 6p12
• Pathway: Glycine, serine and threonine metabolism, organism-specific biosystem; Glycine, serine and threonine metabolism, conserved biosystem
• Function: folic acid binding; glycine N-methyltransferase activity; glycine binding; protein binding; transferase activity