Recombinant Human GSS, His-tagged

• Cat.No.: GSS-26092TH
• Product Overview: Recombinant full length protein, corresponding to amino acids 1-474 of Human Glutathione Synthetase with N terminal His tag, MWt 56kDa.

Specification

• Description: Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 41 μl aqua dest.
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPT SSEVVSYAPFTLFPSLVPSALLEQAYAVQMDFNLLVDA VSQNAAFLEQTLSSTIKQDDFTARLFDIHKQVLKEGIA QTVFLGLNRSDYMFQRSADGSPALKQIEINTISASFGG LASRTPAVHRHVLSVLSKTKEAGKILSNNPSKGLALGIAK AWELYGSPNALVLLIAQEKERNIFDQRAIENELLARNI HVIRRTFEDISEKGSLDQDRRLFVDGQEIAVVYFRDGY MPRQYSLQNWEARLLLERSHAAKCPDIATQLAGTKKVQ QELSRPGMLEMLLPGQPEAVARLRATFAGLYSLDVGEE GDQAIAEALAAPSRFVLKPQREGGGNNLYGEEMVQALKQL KDSEERASYILMEKIEPEPFENCLLRPGSPARVVQCIS ELGIFGVYVRQEKTLVMNKHVGHLLRTKAIEHADGGVA AGVAVLDNPYPV
• Sequence Similarities: Belongs to the eukaryotic GSH synthase family.

Gene Information

• Gene Name: GSS glutathione synthetase [ Homo sapiens ]
• Official Symbol: GSS
• Synonyms: GSS; glutathione synthetase
• Gene ID: 2937
• mRNA Refseq: NM_000178
• Protein Refseq: NP_000169
• MIM: 601002
• Uniprot ID: P48637
• Chromosome Location: 20q11.2
• Pathway: Biological oxidations, organism-specific biosystem; Glutathione biosynthesis, glutamate => glutathione, organism-specific biosystem; Glutathione biosynthesis, glutamate => glutathione, conserved biosystem
• Function: ATP binding; glutathione binding; glutathione synthase activity; glycine binding; ligase activity