Recombinant Human GTF2B

• Cat.No.: GTF2B-30662TH
• Product Overview: Recombinant full length human TFIIB with proprietary tag, Estimated MWt 61kDa.

Specification

• Description: This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the TFIIB family.Contains 1 TFIIB-type zinc finger.

Gene Information

• Gene Name: GTF2B general transcription factor IIB [ Homo sapiens ]
• Official Symbol: GTF2B
• Synonyms: GTF2B; general transcription factor IIB; transcription initiation factor IIB; TFIIB
• Gene ID: 2959
• mRNA Refseq: NM_001514
• Protein Refseq: NP_001505
• MIM: 189963
• Uniprot ID: Q00403
• Chromosome Location: 1p22-p21
• Pathway: Basal transcription factors, organism-specific biosystem; Basal transcription factors, conserved biosystem; Eukaryotic Transcription Initiation, organism-specific biosystem; Formation and Maturation of mRNA Transcript, organism-specific biosystem; Gene Expression, organism-specific biosystem
• Function: DNA binding; metal ion binding; protein binding; thyroid hormone receptor binding; transcription factor binding