Recombinant Human HDAC6
Cat.No. : | HDAC6-28922TH |
Product Overview : | Recombinant full length protein (Human), N-Terminal Tag. |
- Specification
- Gene Information
- Related Products
Description : | Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. |
Biological activity : | Activity: 50 U/ug. One U =1 pmol/min, Assay condition: 25 mM Tris/Cl,pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 uM Biomol substrate (Catalog number KI177), and 5 ng/ul HDAC6. Incubation condition: 60 min at 30oC. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 50mM Tris HCl, 20mM Glutathione, 138mM Sodium chloride, pH 8 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the histone deacetylase family. HD type 2 subfamily.Contains 1 UBP-type zinc finger. |
Gene Name : | HDAC6 histone deacetylase 6 [ Homo sapiens ] |
Official Symbol : | HDAC6 |
Synonyms : | HDAC6; histone deacetylase 6; FLJ16239; HD6; JM21; KIAA0901; |
Gene ID : | 10013 |
mRNA Refseq : | NM_006044 |
Protein Refseq : | NP_006035 |
MIM : | 300272 |
Uniprot ID : | Q9UBN7 |
Chromosome Location : | Xp11.23 |
Pathway : | Cell cycle, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class II, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem; |
Function : | Hsp90 protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); actin binding; |
Products Types
◆ Recombinant Protein | ||
HDAC6-4092M | Recombinant Mouse HDAC6 Protein, His (Fc)-Avi-tagged | +Inquiry |
HDAC6-1055H | Recombinant Human HDAC6 Protein, His (Fc)-Avi-tagged | +Inquiry |
HDAC6-2236H | Recombinant Human HDAC6 Protein, His-tagged | +Inquiry |
HDAC6-958P | Recombinant Pig HDAC6 Protein, His-tagged | +Inquiry |
HDAC6-1877R | Recombinant Rhesus Macaque HDAC6 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HDAC6-5603HCL | Recombinant Human HDAC6 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-1742 | HDAC6 Fluorogenic Assay Kit | +Inquiry |
Kit-1028 | HDAC6 Activity Assay Kit (Fluorometric) | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, HDAC6 inhibitors can be combined with other therapies for enhanced efficacy. Synergistic effects may include improved anti-cancer activity or neuroprotection.
Yes, there are clinical trials exploring HDAC6 inhibitors as potential treatments. Positive outcomes could lead to new therapeutic options for patients.
HDAC6 is implicated in neurodegenerative diseases and inflammatory disorders. Understanding its role could lead to novel therapeutic approaches for these conditions.
HDAC6 regulates cell motility, protein trafficking, and other processes. Understanding these mechanisms is crucial for developing targeted therapies in various diseases.
Genetic variations in HDAC6 may influence individual responses to treatments. Personalized medicine approaches could consider these variations for better outcomes.
Customer Reviews (3)
Write a reviewTheir expertise and guidance have helped overcome hurdles, ensuring the smooth progress of my research.
The bands of proteins in Western Blotting experiments were very clear.
Its purity and consistency have provided me with reliable and reproducible results, ensuring the accuracy of my research findings.
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