Recombinant Human HLA-DPB1

• Cat.No.: HLA-DPB1-30198TH
• Product Overview: Recombinant full length Human HLA DPB1 with N terminal proprietary tag; Predicted MWt 54.49 kDa.

Specification

• Description: HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
• Protein length: 258 amino acids
• Molecular Weight: 54.490kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYVYQG RQECYAFNGTQRFLERYIYNREEYARFDSDVGEFRAVT ELGRPAAEYWNSQKDILEEKRAVPDRVCRHNYELDEAVTL QRRVQPKVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQV RWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGD VYICQVEHTSLDSPVTVEWKAQSDSAQSKTLTGAGGFV LGLIICGVGIFMHRRSKKVQRGSA

Gene Information

• Gene Name: HLA-DPB1 major histocompatibility complex, class II, DP beta 1 [ Homo sapiens ]
• Official Symbol: HLA-DPB1
• Synonyms: HLA-DPB1; major histocompatibility complex, class II, DP beta 1; HLA DP1B; HLA class II histocompatibility antigen, DP beta 1 chain
• Gene ID: 3115
• mRNA Refseq: NM_002121
• Protein Refseq: NP_002112
• MIM: 142858
• Uniprot ID: P04440
• Chromosome Location: 6p21.3
• Pathway: Adaptive Immune System, organism-specific biosystem; Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem